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Among other highlights in his journalism career, Anderson won a Pulitzer prize in 1972 for uncovering President Richard Nixon's and then Secretary of State Henry Kissinger's secret alliance with Pakistan in the India-Pakistan war. Prior to this scathing expose, the American public had been led to believe that the United States was neutral in this war. FREEDOM Magazine is dedicated to investigative reporting in the public interest. Published since 1968 by the Church of Scientology, the magazine has won awards on state and national levels for insightful reporting on a wide range of issues. FREEDOM highlights the good works of those who are championing the causes of human rights, drug rehabilitation, drug education and social and government reform. It has a long record of exposing abuses, corruption and violations of individual rights and freedoms. Others receiving FREEDOM's Human Rights Leadership Awards are retired Congressman John Moss D-Third District, Calif. ; and "father of the Freedom of Information Act"; the Hon. Annette Polly Williams, Wisconsin State Assembly Representative D-17th District ; and proponent for the Parental School Choice Program; the Hon. Harry Reid, U.S. Senator D-Nev. ; , and advocate for IRS Reform; and psychoanalyst and author Dr. Thomas Szasz, pioneer of the anti-psychiatry movement. FREEDOM Human Rights Leadership Awards are presented to honor selected individuals for their outstanding accomplishments in protecting basic rights. FREEDOM Magazine will release a special issue commemorating the achievements of these individuals at the awards dinner on Feb. 5. Contact: Susan Taylor of FREEDOM Magazine, 202-543-6404. Human rights advocate congressman John Moss to be honored at Freedom Magazine Awards Ceremony The following was released today by Freedom Magazine: For 26 years, Democratic Rep. John Moss represented the Third Congressional District of California. In a tribute to his efforts in safeguarding individual rights during his longspanning career, Moss is one of the recipients to be presented with Freedom Magazine's 1992 Human Rights Leadership Award for exemplary leadership in the cause of human rights and freedom. Moss will be honored at the National Press Club in Washington, D.C., on Wednesday, Feb. 5. The award will be presented by Freedom Magazine's Editor-in-Chief, Tom Whittle. During his tenure in Congress, Congressman Moss was a senior member of two major standing Committees of the House, including the Interstate and Foreign Commerce Committee now known as the Energy and Commerce Committee ; and the Government Operations Committee. Moss was principal author of the widely acclaimed Freedom of.
FDA Classification of Drug Safety During Pregnancy: B Either animal reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animal reproduction studies have shown an adverse effect other than a decrease in fertility ; that was not confirmed in controlled studies in women in the first trimester and there is no evidence of risk in later trimesters. C Human studies are lacking, and animal studies are either positive for fetal risk or lacking. Risk cannot be ruled out, however potential benefits may justify potential risks. D There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk eg, if the drug is needed in a life-threatening situation or for a serious disease in which safer drugs cannot be used or are ineffective.
Rosiglitazone 4 mg day 2 mg 500 mg 1 tablet bd 8 mg day 4 mg 500 mg 1 tablet bd * for patients on doses of metformin hcl between 1000 and 2000 mg day, initiation of avandamet requires individualization of therapy.
Table 9. Adverse Events 5% in Any Treatment Group ; Reported by Patients in 26-week Double-blind Clinical Trials of Rosiglitazone Added to Metformin Therapy Rosiglitazone plus Rosiglitazone Placebo Metformin metformin N 2, 526 N 601 N 225 N 338 Preferred term % % % % Upper respiratory 9.9 8.7 8.9 tract infection Injury 7.6 4.3 7.6 Headache 5.9 5.0 8.9 Back pain 4.0 3.8 4.0 Hyperglycemia 3.9 5.7 4.4 Fatigue 3.6 5.0 4.0 Sinusitis 3.2 4.5 5.3 Diarrhea 2.3 3.3 15.6 Viral infection 3.2 4.0 3.6 Arthralgia 3.0 4.0 2.2 Anemia 1.9 0.7 2.2 In the double-blind trial evaluating AVANDAMET in drug-nave patients, mild no intervention required ; to moderate minor intervention required ; symptomatic hypoglycemia was reported by 18 155 12% ; of patients treated with AVANDAMET, 14 154 9% ; with metformin, and 13 159 8% ; with rosiglitazone. Approximately half of these episodes were accompanied by a simultaneous capillary glucose measurement, and the rate of confirmed hypoglycemia blood glucose 50mg dL ; was low in this clinical study: 0.6% 1 155 ; for AVANDAMET, 1.3% 2 154 ; for metformin and 0% with rosiglitazone. No hypoglycemic episode led to withdrawal with AVANDAMET treatment, and no patients required medical intervention due to hypoglycemia. Reports of hypoglycemia in patients treated with rosiglitazone added to maximum metformin therapy in double-blind studies were more frequent 3.0% ; than in patients treated with rosiglitazone 0.6% ; or metformin monotherapies 1.3% ; or placebo 0.2% ; . Overall, anemia and edema were generally mild to moderate in severity and usually did not require discontinuation of treatment with rosiglitazone. In the double-blind trial in drug-nave patients, the incidence of edema was 6% on AVANDAMET compared to 7% on rosiglitazone and 3% on metformin. In the double-blind trial in drug-nave patients, the incidence of anemia was 4% in patients treated with AVANDAMET compared to either rosiglitazone 2% ; or metformin 0% ; . Reports of anemia 7.1% ; were greater in patients treated with rosiglitazone added to metformin compared to monotherapy with rosiglitazone. Lower pre-treatment hemoglobin hematocrit levels in patients enrolled in the metformin and rosiglitazone combination therapy clinical trials may 27.
Servings per day of fruits and vegetables, 30 minutes per day of physical activity on most if not all days, and blood pressure at 130 mmHg systolic and 85 mmHg diastolic. With respect to smoking, Dr. Kottke observed that asthma prevalence is increasing, particularly in the younger age set. "We want to raise a generation of children who think the house is on fire when they smell smoke, " he said. Important initiatives have been taken as part of the programme to promote smoke-free restaurants and similar areas. The goal can also be met by drinking fruit juices on a regular basis.
ATACAND candesartan ; . 15 ATACAND HCT candesartan hydrochlorothiazide ; . 15 atenolol . 15 atenolol and chlorthalidone. 15 ATRIPLA Efavirenz Emtricitabine Tenofovir ; . 8 atropine sulfate ophthalmic ; . 24 ATROVENT HFA Ipratropium Bromide HFA ; . 14 ATTENUVAX Measles Virus Vaccine ; . 31 aug betamethasone dipropionate. 32 AUGMENTIN Amoxicillin and Pot Clavulanate ; . 8 AUMENTIN XR TAB SR. 8 AVALIDE irbesartan hydrochlorothiazide ; . 15 AVANDAMET Rosiglitazone Maleate-Metformin HCl ; . 28 AVANDIA Rosiglitazone Maleate ; . 28 AVAPRO irbesartan ; . 15 AVASTIN Bevacizumab ; . 12 AVELOX Moxifloxacin HCl in Sodium Chloride ; . 8 AVELOX ABC Moxifloxacin HCl ; . 8 AVINZA CAP CR . 18 AVODART Dutasteride ; . 35 AVONEX Interferon Beta-1a ; . 35 azathioprine . 35 AZELEX Azelaic Acid Acne . 32 azithromcyin. 8 AZMACORT AER . 14 AZOPT Brinzolamide ; . 24 bacitracin ophthalmic ; . 24 bacitracin-polymyxin b ophth ; . 24 bacitracin-poly-neomycin-hc . 24 baclofen. 14 BACTROBAN CRE 2%. 32 BARACLUDE . 8 B-D INSULIN SYRINGE Insulin Syringes Disposable . 37 benazepril and hydrochlorothiazide . 15 benazepril hcl. 15 BENICAR HCT TAB . 15 BENICAR TAB 40MG. 15 BENICAR TAB 5MG, 20mg . 15 BENZACLIN GEL 1-5% . 32 benzocaine and antipyrine . 24 benzoyl peroxide . 32 benzoyl peroxide-erythromycin. 32 benztropine mesylate. 14 betamethasone dipropionate topical ; . 32 betamethasone valerate . 32 * This prescription drug is not normally covered in a Medicare Prescription Drug Plan. The amount you pay when you fill a prescription for this drug does not count towards your total drug costs that is, the amount you pay does not help you qualify for catastrophic coverage.
NDA 21-410 S-023 Page 19 Table 7. Weight Changes kg ; From Baseline at Endpoint During Clinical Trials [Median 25th, 75th, Percentile ; ] Monotherapy Duration Control Group Rosiglitazone 4 mg Rosiglitazone 8 mg 26 Placebo 0.9 2.8, 0.9 ; 1.0 0.9, 3.6 ; 3.1 1.1, 5.8 ; weeks n 210 n 436 n 439 52 Sulfonylurea 2.0 0, 4.0 ; 2.0 0.6, 4.0 ; 2.6 0, 5.3 ; weeks n 173 n 150 n 157 Combination Therapy Rosiglitazone plus Control Therapy Duration Control Group Rosiglitazone 4 mg Rosiglitazone 8 mg 24-26 Sulfonylurea 0 1.0, 1.3 ; 2.2 0.5, 4.0 ; 3.5 1.4, 5.9 ; weeks n 1, 155 n 613 n 841 26 wee Metformin 1.4 3.2, 0.2 ; 0.8 1.0, 2.6 ; 2.1 0, 4.3 ; ks n 175 n 100 n 184 26 wee Insulin 0.9 0.5, 2.7 ; 4.1 1.4, 6.3 ; 5.4 3.4, 7.3 ; ks n 162 n 164 n 150 AVANDAMET in Drug Nave Patients Duration Control Groups AVANDAMET Metformin 2.2 5.5, 0.5 ; 32 n 123 0.05 kg 3.45, 3.0 ; weeks n 136 Rosiglitazone 1.7 1.2, 4.5 ; n 136 AVANDAMET plus Insulin Duration Control Group AVANDAMET plus INSULIN 24 Insulin 2.6 kg 0.3, 4.8 ; 3.3 kg 1.5, 6.0 ; weeks n 145 n 147 In postmarketing experience with rosiglitazone alone or in combination with other hypoglycemic agents, there have been rare reports of unusually rapid increases in weight and increases in excess of that generally observed in clinical trials. Patients who experience such increases should be assessed for fluid accumulation and volume-related events such as excessive edema and congestive heart failure see BOXED WARNING ; . Hematologic: Across all controlled clinical studies in adults, decreases in hemoglobin and hematocrit mean decreases in individual studies of approximately 1.0 gram dL and 3.3%, respectively ; were observed for rosiglitazone maleate alone and in combination with other hypoglycemic agents. The changes occurred primarily during the first 3 months following initiation of rosiglitazone therapy or following an increase in rosiglitazone dose. The decrease in hemoglobin was seen more frequently in combination rosiglitazone and metformin therapy than in rosiglitazone therapy alone. Vitamin B12 deficiency may contribute to the observed reductions in hemoglobin see PRECAUTIONS, Metformin hydrochloride, Vitamin B12 levels ; . White blood cell counts also decreased slightly in adult patients treated with rosiglitazone. Small decreases in hemoglobin and hematocrit have also been reported in pediatric patients treated with rosiglitazone. The observed changes may be related to the increased plasma volume observed with treatment with rosiglitazone and may be dose related see ADVERSE REACTIONS, Laboratory Abnormalities and glucotrol.
REFERENCES Endocrine: Diabetes Insulins 1. 2. Clinical Pharmacology. : cpip.gsm [cited 2003 December 12]. Eli Lilly and Company. Humalog insulin lispro ; prescribing information. Indianapolis IN ; : Revised 2002. 3. Novo Nordisk Pharmaceuticals, Inc. Human Insulin Products. Princeton NJ ; : 2000. 4. Aventis. Lantus insulin glargine ; prescribing information. Kansas City MO ; : Revised 2003. 5. Rosenstock J, Schwartz SL, Clark CM, et al. Basal insulin therapy in type 2 diabetes. Diabetes Care 2001; 24 4 ; : 631-636. 6. Zinman B, Ross S, Campos RV, et al. Effectiveness of human ultralente versus NPH insulin in providing basal insulin replacement for an insulin lispro multiple daily injection regimen. Diabetes Care 1999; 22 4 ; : 603-608. 7. Hermansen K, Colombo M, Storgaard H, et al. Improved postprandial glycemic control with biphasic insulin aspart relative to biphasic insulin lispro and biphasic human insulin in patients with type 2 diabetes. Diabetes Care 2002; 25 5 ; : 883-888. 8. Roach P, Yue L, Arora V, et al. Improved postprandial glycemic control during treatment with Humalog Mix25, a novel protamine-based insulin lispro formulation. Diabetes Care 1999; 22 8 ; : 1258-1261. 9. Roach P, Trautmann M, Arora V, et al. Improved postprandial blood glucose control and reduced nocturnal hypoglycemia during treatment with two novel insulin lispro-protamine formulations, insulin lispro mix25 and insulin lispro mix50. Clinical Therapeutics 1999; 21 3 ; : 523-534. 10. Roach P, Strack T, Arora V, et al. Improved glycemic control with the use of selfprepared mixtures of insulin lispro and insulin lispro protamine suspension in patients with types 1 and 2 diabetes. International Journal of Clinical Practice 2001; 55 3 ; : 177182. 11. Raskin P, Klaff L, Bergenstal, et al. A 16-week comparison of the novel insulin analog insulin glargine HOE 901 ; and NPH human insulin used with insulin lispro in patients with type 1 diabetes. Diabetes Care 2000; 23 11 ; : 1666-1671. 12. Orange book. Accessed at fda.gov cder ob default on 12 03: patent expiration dates REFERENCES Endocrine: Oral Hypoglycemics 1. 2. 3. Clinical Pharmacology 2006. [accessed 2006 April]. Available from: URL: : cpip.gsm . Drugsnikolov Drugs USPDI Micromedex ; AHFS Drug Information 2002, 3018-3047 MerckMedicus Drug References GenRx Mosby's GenRx ; Drug Info Index 2002 Glipizide package insert, Mylan-US ; , Rev May 2001 Glimepride package insert, Aventis-US ; , Rev July 2001 Glyburide package insert, Geneva-US ; , Rev April 2002 Glucophage, Physicians Desk Reference 2002, 1080-1086 Precose package insert. Bayer Corporation. West Haven CT. 2001 Glyset package insert. Pharmacia & Upjohn Company. West Haven CT. 2002 Starlix package insert. Novartis Pharmaceutical. East Hanover NJ. December 2000 Prandin package insert. Novo Nordisk Pharmaceuitical. Princetion, NJ. October 2002 Metaglip Package Insert. Bristol-Myers Squibb Company, Princeton, NJ 2002 Glucovance Package Insert. Bristol-Myers Squibb Company, Princeton, NJ 2002 Avanadmet Package Insert. GlaxoSmithKline, Teserach Triangle Park, NC 2002 UK Prospective Diabetes Study UKPDS ; group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 1998; 352: 837-53.
In the event coverage terminates for any reason, a written Certification of Creditable Coverage will be issued to you. The Certification of Creditable Coverage will indicate the period of time you were enrolled under FCCRMC's Group Health Plan. Creditable Coverage may reduce the length of any Pre-existing Condition exclusionary period by the length of time you had prior Creditable Coverage. Upon request, another Certification of Creditable Coverage will be sent to you within a 24-month period after termination of coverage. The succeeding carrier will be responsible for determining if coverage meets the qualifying Creditable Coverage guidelines e.g., no more than a 63-day break in coverage and prandin.
Heart failure risk may be increased in patients with diabetes who take any of the thiazolidinedione antidiabetic drugs. Black box warnings about the risk will be added to the labels for Avandia rosiglitazone ; , Actos pioglitazone ; , Avandaryl rosiglitazone and glimepiride ; , Agandamet rosiglitazone and metformin ; , and Duetact pioglitazone and glimepiride ; . fda.gov medwatch safety 2007 safety07 #rosi pio Unauthorized lovastatin Mevacor ; has been found in 3 red-yeast products marketed as dietary supplements for reducing cholesterol. Use of the products Red Yeast Rice, Cholestrix, and Red Yeast Rice Policonsonal Complex, can cause serious muscle-related adverse events and kidney impairment particularly in patients taking other medications known to interact with lovastatin. Side effects of AvandametBuilding a Better Delivery System: A New Engineering Health Care Partnership. National Academy of Engineering and the Institute of Medicine, National Academies Press, Proctor P. Reid, W. Dale Compton, Jerome H. Grossman, and Gary Fanjiang, Editors, Committee on Engineering and the Health Care System, Chapter 3, pgs. 2762 and amaryl. Like many American taxpayers, until recently I believed that the Office of Alternative Medicine OAM ; , within the National Institutes of Health in Washington, D.C., was there to provide citizens with information about alternatives in disease treatment. When I recently inquired what OAM had on alternative cancer treatments, I was shocked to discover that all they offer is party-line conventional methods courtesy of the National Cancer Institute NCI ; which seems to exist solely to spend billions of taxpayer dollars on unproductive research and the suppression of effective alternatives. Until earlier this year, OAM sent out a free copy of the "Cancer" chapter from our Alternative Medicine: The Definitive Guide to those who needed information on alternative cancer treatments. This has stopped abruptly. Now OAM sends out a 3-page statement that dismisses "unconventional" treatments as being essentially worthless and unproven. Here's what their "Cancer Facts" sheet says: First, "Many proponents of unconventional methods of cancer treatment make claims that are not or cannot be scientifically confirmed." The proof is in the clinic. Ask the patients who have been healed; study the medical reports of the doctors who have produced these healings. Science is based on real observation, not abstract theory. Alternative physicians observe their patients and adjust accordingly. I ask the NCI: where is the scientific proof for the claims that chemotherapy, radiation, and surgery are effective in treating cancer? The proof does not exist. Second, "Practitioners of unconventional treatments are held to the same research standards as those of any scientist." This means they must be evaluated in controlled double-blind clinical trials. This is impossible and inappropriate given the way alternative therapies work. They are based on a multifaceted treatment; very often an "unconventional" cancer doctor uses several dozen substances and therapies at the same time to get the best combined effect. There is no single magic bullet in the alternative approach; conventional research standards are worthless with respect to proving what works in our kind of medicine. Further, each patient is different and needs a different dosage and combination of remedies. There is no single boilerplate recipe for treating cancer. Third, the OAM paper advises readers that "because treatments for cancer must be very powerful, they frequently have unpleasant side effects." This is shameful. Of course chemotherapy and radiation are powerful: like a nuclear bomb, they kill everything in sight. The side effects are not "unpleasant; " they are always toxic and sometimes fatal. There are almost always no "side effects" in alternative cancer approaches; there are only healing effects because the remedies and therapies actually work with the body, not against. Fourth, OAM states that if you use unconventional methods this "may result in the loss of valuable time and the opportunity to receive potentially effective therapy." This "consequently reduces a patient's chances for cure or control of cancer." Since when does conventional oncology ever talk in terms of "cure"?. Member States have to ensure that multiple sclerosis is detected at the earliest possible stage. 2 ; Member States also have to make sure that patients diagnosed with MS do have access to proper treatment and that they receive the most effective medication possible. Around the world, research efforts in the area of multiple sclerosis are enormous. Experts are expecting to see even more effective treatments in the near future. The rapid developments that take place in molecular biology, genetics, immunology and neurology research do all nourish the hope for even greater advances in the near future. This is where we as policymakers are challenged: it is our main goal, and it is also our responsibility, to make new and improved treatment possibilities available to all affected persons as soon as possible and lamisil.
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A ACCU-CHEK BLOOD GLUCOSE METER ACCU-CHEK TEST STRIPS ACCUNEB ACIPHEX ACTIVELLA ACTOS ACULAR ADVAIR AGENERASE AGRYLIN ALINIA ALLEGRA ALLEGRA-D ALPHAGAN P ALTACE AMARYL AMBIEN ANDROGEL ARICEPT ARIMIDEX AROMASIN ARTHROTEC to be deleted, effective April 30, 2005 ; ASACOL ASCENSIA TEST STRIPS ASTELIN ATROVENT AVALIDE AVANDAMET AVANDIA AVAPRO AVONEX AZMACORT B BD TEST STRIPS BETASERON BETIMOL to be deleted, effective April 30, 2005 ; BEXTRA to be deleted, effective April 30, 2005 ; BRAVELLE C CAFERGOT CANASA CARAC CARDIZEM LA CASODEX CEENU CELEBREX CELLCEPT CENESTIN CERUMENEX to be deleted, effective April 30, 2005 ; CETROTIDE CIPRODEX CLIMARA CLIMARA PRO COMBIVENT COMBIVIR COMTAN CONCERTA CONDYLOX GEL COPAXONE COPEGUS COREG CORTEF CORTIFOAM COZAAR CREON CRIXIVAN CUPRIMINE CYTOXAN D DANTRIUM to be deleted, effective April 30, 2005 ; DAPSONE DEPAKOTE DEPAKOTE ER DEPAKOTE SPRINKLE DETROL DILANTIN DIPENTUM DOSTINEX DOVONEX DUONEB DURAGESIC E EFFEXOR EFFEXOR XR EFUDEX CREAM ELMIRON to be deleted, effective April 30, 2005 ; EMCYT ENTOCORT EC EPINEPHRINE INJECTION EPIVIR EPIVIR-HBV EPZICOM ERGAMISOL ESCLIM to be deleted, effective April 30, 2005 ; ESTRADERM ESTRATEST ESTRATEST HS ETHMOZINE EVISTA EVOXAC EXELON F FARESTON FEMARA FINACEA FLOMAX FLONASE FLOVENT FLOVENT ROTADISK FLOXIN OTIC FLUOROPLEX to be deleted, effective April 30, 2005 ; FORADIL AEROLIZER FORTOVASE FOSAMAX FREESTYLE TEST STRIPS FULVICIN P G FULVICIN U F G GLEEVEC GLUCAGON GLUCO-DEX TEST STRIPS GLUCOSTIX TEST STRIPS H HELIDAC HEPSERA HEXALEN HIVID HYZAAR I IMITREX, all forms INFERGEN to be deleted, effective April 30, 2005 ; INNOPRAN XL INTAL INHALER INTRON A INVIRASE K KALETRA, capsule and solution KEPPRA KYTRIL L LAMICTAL LAMISIL LESCOL LESCOL XL LEUKERAN LEVAQUIN LEVBID LEVSINEX to be deleted, effective April 30, 2005 ; LEXAPRO LEXIVA LIDODERM LIPITOR LOPROX TOPICAL CREAM AND GEL LOTEMAX LOVENOX LUMIGAN LYSODREN M MALARONE to be deleted, effective April 30, 2005 ; MAXALT MEPHYTON METADATE CD METADATE ER METHERGINE METROGEL VAGINAL MIACALCIN MIGRANAL MIRAPEX MYLERAN MYLOCEL N NAMENDA NARDIL NASONEX NEUPOGEN NIASPAN NILANDRON NORITATE NORVASC NORVIR NOVOLIN NOVOLOG NOVOLOG MIX 70 30 NULEV to be deleted, effective April 30, 2005 ; NUTROPIN NUTROPIN AQ NUTROPIN DEPOT NUVARING O ONE TOUCH GLUCOMETER ONE TOUCH TEST STRIP ORTHO EVRA ORTHO TRI-CYCLEN LO OVIDE OXSORALEN ULTRA OXYCONTIN OXYTROL P PARNATE PEGASYS PEG-INTRON PHOSLO PLAN B PLAVIX PRANDIN PRAVACHOL PRECOSE PRED MILD PREDNISONE 1mg PREMARIN PREMARIN CREAM PREMPHASE PREMPRO PREVEN PROCTOFOAM HC PROGRAF PROSCAR PROTOPIC to be deleted, effective April 30, 2005 ; PRO VIGIL PULMICORT RESPULES PULMICORT TURBUHALER PULMOZYME Q QUIXIN QVAR R RAPAMUNE REBETRON REBIF RELPAX to be deleted, effective April 30, 2005; alternative is MAXALT ; * REMINYL RENAGEL REQUIP RESCRIPTOR RESTASIS RESTORIL--7.5mg DOSE ONLY RETIN-A MICRO RETROVIR RHINOCORT AQUA RIDAURA RISPERDAL S SAIZEN SEREVENT SEREVENT DISKUS SEROQUEL SINGULAIR SONATA SPIRIVA STALEVO and diflucan and Buy cheap avandamet online.
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